Structural Organization of the RNA Polymerase-Promoter Open Complex

@article{Naryshkin2000StructuralOO,
  title={Structural Organization of the RNA Polymerase-Promoter Open Complex},
  author={N. Naryshkin and A. Revyakin and Younggyu Kim and V. Mekler and R. Ebright},
  journal={Cell},
  year={2000},
  volume={101},
  pages={601-611}
}
We have used systematic site-specific protein-DNA photocrosslinking to define interactions between bacterial RNA polymerase (RNAP) and promoter DNA in the catalytically competent RNAP-promoter open complex (RPo). We have mapped more than 100 distinct crosslinks between individual segments of RNAP subunits and individual phosphates of promoter DNA. The results provide a comprehensive description of protein-DNA interactions in RPo, permit construction of a detailed model for the structure of RPo… Expand
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