Structural Modification of Lipopolysaccharide Conferred by mcr-1 in Gram-Negative ESKAPE Pathogens.

@article{Liu2017StructuralMO,
  title={Structural Modification of Lipopolysaccharide Conferred by mcr-1 in Gram-Negative ESKAPE Pathogens.},
  author={Yi-yun Liu and Courtney E Chandler and Lisa M. Leung and Christi Lee McElheny and Roberta T Mettus and Robert M Q Shanks and Jian-Hua Liu and David R. Goodlett and Robert K Ernst and Yohei Doi},
  journal={Antimicrobial agents and chemotherapy},
  year={2017},
  volume={61 6}
}
mcr-1 was initially reported as the first plasmid-mediated colistin resistance gene in clinical isolates of Escherichia coli and Klebsiella pneumoniae in China and has subsequently been identified worldwide in various species of the family Enterobacteriaceaemcr-1 encodes a phosphoethanolamine transferase, and its expression has been shown to generate phosphoethanolamine-modified bis-phosphorylated hexa-acylated lipid A in E. coli Here, we investigated the effects of mcr-1 on colistin… CONTINUE READING
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