Structural Models of Zebrafish (Danio rerio) NOD1 and NOD2 NACHT Domains Suggest Differential ATP Binding Orientations: Insights from Computational Modeling, Docking and Molecular Dynamics Simulations

@inproceedings{Maharana2015StructuralMO,
  title={Structural Models of Zebrafish (Danio rerio) NOD1 and NOD2 NACHT Domains Suggest Differential ATP Binding Orientations: Insights from Computational Modeling, Docking and Molecular Dynamics Simulations},
  author={Jitendra Maharana and Bikash R. Sahoo and Aritra Bej and Itishree Jena and Arunima Parida and Jyoti Ranjan Sahoo and Budheswar Dehury and Mahesh Chandra Patra and Sushma Rani Martha and Sucharita Balabantray and Sukanta Kumar Pradhan and Bijay Kumar Behera},
  booktitle={PloS one},
  year={2015}
}
Nucleotide-binding oligomerization domain-containing protein 1 (NOD1) and NOD2 are cytosolic pattern recognition receptors playing pivotal roles in innate immune signaling. NOD1 and NOD2 recognize bacterial peptidoglycan derivatives iE-DAP and MDP, respectively and undergoes conformational alternation and ATP-dependent self-oligomerization of NACHT domain followed by downstream signaling. Lack of structural adequacy of NACHT domain confines our understanding about the NOD-mediated signaling… CONTINUE READING

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