Structural Mechanism for the Fidelity Modulation of DNA Polymerase λ.

Abstract

The mechanism of DNA polymerase (pol) fidelity is of fundamental importance in chemistry and biology. While high-fidelity pols have been well studied, much less is known about how some pols achieve medium or low fidelity with functional importance. Here we examine how human DNA polymerase λ (Pol λ) achieves medium fidelity by determining 12 crystal… (More)
DOI: 10.1021/jacs.5b13368

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