Structural Mapping of Adenosine Receptor Mutations: Ligand Binding and Signaling Mechanisms.

Abstract

The four adenosine receptors (ARs), A1, A2A, A2B, and A3, constitute a subfamily of G protein-coupled receptors (GPCRs) with exceptional foundations for structure-based ligand design. The vast amount of mutagenesis data, accumulated in the literature since the 1990s, has been recently supplemented with structural information, currently consisting of several… (More)
DOI: 10.1016/j.tips.2017.11.001

Topics

  • Presentations referencing similar topics