Structural Investigations of N-carbamoylputrescine Amidohydrolase from Medicago truncatula: Insights into the Ultimate Step of Putrescine Biosynthesis in Plants

@inproceedings{Sekula2016StructuralIO,
  title={Structural Investigations of N-carbamoylputrescine Amidohydrolase from Medicago truncatula: Insights into the Ultimate Step of Putrescine Biosynthesis in Plants},
  author={Bartosz Sekula and Milosz Ruszkowski and Maura Malińska and Zbigniew Dauter},
  booktitle={Front. Plant Sci.},
  year={2016}
}
Putrescine, 1,4-diaminobutane, is an intermediate in the biosynthesis of more complexed polyamines, spermidine and spermine. Unlike other eukaryotes, plants have evolved a multistep pathway for putrescine biosynthesis that utilizes arginine. In the final reaction, N-carbamoylputrescine is hydrolyzed to putrescine by N-carbamoylputrescine amidohydrolase (CPA, EC 3.5.1.53). During the hydrolysis, consecutive nucleophilic attacks on the substrate by Cys158 and water lead to formation of putrescine… CONTINUE READING
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References

Publications referenced by this paper.
SHOWING 1-10 OF 90 REFERENCES

The Protein Data Bank.

  • Nucleic acids research
  • 2000
VIEW 5 EXCERPTS
HIGHLY INFLUENTIAL

Cross-talk between reactive oxygen species

O. Dobrovinskaya
  • 2014

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