Structural Insights into the Mechanism of Phosphoenolpyruvate

Abstract

Mammalian PEPCK catalyzes the reversible formation of PEP from OAA and GTP (or ITP) in a divalent cation-dependent reaction (Scheme 1), as was elegantly discussed in the first minireview of this series on PEPCK (1). In this third minireview, high-resolution crystal structures of mammalian PEPCK are examined to gain insights into the mechanism of PEPCK… (More)

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2 Figures and Tables