Structural Insights into WD-Repeat 48 Activation of Ubiquitin-Specific Protease 46.

  title={Structural Insights into WD-Repeat 48 Activation of Ubiquitin-Specific Protease 46.},
  author={Jianping Yin and Allyn J. Schoeffler and Katherine E. Wickliffe and Kim Newton and Melissa A. Starovasnik and Erin C. Dueber and Seth F. Harris},
  volume={23 11},
Protein ubiquitination patterns are an important component of cellular signaling. The WD-repeat protein WDR48 (USP1-associated factor UAF-1) stimulates activity of ubiquitin-specific proteases USP1, USP12, and USP46. To understand how WDR48 exerts its effect on the USP scaffold, we determined structures of the ternary WDR48:USP46:ubiquitin complex. WDR48 interacts with the USP46 fingers subdomain via a relatively small, highly polar surface on the top center of the WDR48 β propeller. In… CONTINUE READING

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