Structural Insights into Thermotoga maritima FtsH Periplasmic Domain on Substrate Recognition

Abstract

Prompt removal of misfolded membrane proteins and misassembled membrane protein complexes is essential for membrane homeostasis. However, the elimination of these toxic proteins from the hydrophobic membrane environment has high energetic barriers. Transmembrane FtsH is the only known ATP-dependent protease responsible for this task, unlike other well… (More)

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