Structural Insights into Neutrophilic Migration Revealed by the Crystal Structure of the Chemokine Receptor CXCR2 in Complex with the First PDZ Domain of NHERF1

@inproceedings{Lu2013StructuralII,
  title={Structural Insights into Neutrophilic Migration Revealed by the Crystal Structure of the Chemokine Receptor CXCR2 in Complex with the First PDZ Domain of NHERF1},
  author={Guorong Lu and Yanning Wu and Yuanyuan Jiang and Shuo Wang and Yuning Hou and Xiaoqing Guan and Joseph S. Brunzelle and Nualpun Sirinupong and Shijie Sheng and Chunying Li and Zhe Yang},
  booktitle={PloS one},
  year={2013}
}
Neutrophil plays an essential role in host defense against infection, but uncontrolled neutrophilic infiltration can cause inflammation and severe epithelial damage. We recently showed that CXCR2 formed a signaling complex with NHERF1 and PLC-2, and that the formation of this complex was required for intracellular calcium mobilization and neutrophilic transepithelial migration. To uncover the structural basis of the complex formation, we report here the crystal structure of the NHERF1 PDZ1… CONTINUE READING

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