Structural Insights into Human Peroxisome Proliferator Activated Receptor Delta (PPAR-Delta) Selective Ligand Binding

@inproceedings{Batista2012StructuralII,
  title={Structural Insights into Human Peroxisome Proliferator Activated Receptor Delta (PPAR-Delta) Selective Ligand Binding},
  author={Fernanda Aparecida Heleno Batista and Daniela B B Trivella and Amanda Bernardes and Joyce Gratieri and Paulo Sergio Lopes Oliveira and Ana Carolina Migliorini Figueira and Paul D. Webb and Igor Polikarpov},
  booktitle={PloS one},
  year={2012}
}
Peroxisome proliferator activated receptors (PPARs δ, α and γ) are closely related transcription factors that exert distinct effects on fatty acid and glucose metabolism, cardiac disease, inflammatory response and other processes. Several groups developed PPAR subtype specific modulators to trigger desirable effects of particular PPARs without harmful side effects associated with activation of other subtypes. Presently, however, many compounds that bind to one of the PPARs cross-react with… CONTINUE READING