Structural Insight into the Ion-Exchange Mechanism of the Sodium/Calcium Exchanger

@article{Liao2012StructuralII,
  title={Structural Insight into the Ion-Exchange Mechanism of the Sodium/Calcium Exchanger},
  author={Jun Liao and Hua Li and Weizhong Zeng and David B. Sauer and Ricardo Belmares and Youxing Jiang},
  journal={Science},
  year={2012},
  volume={335},
  pages={686 - 690}
}
Maintaining Equilibrium Na+/Ca2+ exchangers (NCX) are membrane transporters that maintain the homeostasis of cytosolic Ca2+ and play an essential role in Ca2+ signaling. Despite a long history of physiological work and a large body of functional data, the structural basis underlying the ion exchange mechanism of NCX is poorly understood. Liao et al. (p. 686; see the Perspective by Abramson et al.) present a high-resolution crystal structure of an NCX from Methanococcus jannaschii and… Expand
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