Structural Insight into Tetrameric hTRPV1 from Homology Modeling, Molecular Docking, Molecular Dynamics Simulation, Virtual Screening, and Bioassay Validations

@article{Feng2015StructuralII,
  title={Structural Insight into Tetrameric hTRPV1 from Homology Modeling, Molecular Docking, Molecular Dynamics Simulation, Virtual Screening, and Bioassay Validations},
  author={Zhiwei Feng and Larry V. Pearce and Xiaomeng Xu and Xiaole Yang and Peng Yang and Peter M. Blumberg and Xiang-Qun Xie},
  journal={Journal of chemical information and modeling},
  year={2015},
  volume={55 3},
  pages={572-88}
}
The transient receptor potential vanilloid type 1 (TRPV1) is a heat-activated cation channel protein, which contributes to inflammation, acute and persistent pain. Antagonists of human TRPV1 (hTRPV1) represent a novel therapeutic approach for the treatment of pain. Developing various antagonists of hTRPV1, however, has been hindered by the unavailability of… CONTINUE READING