Structural Dynamics of α-Actinin-Vinculin Interactions

@inproceedings{Bois2005StructuralDO,
  title={Structural Dynamics of α-Actinin-Vinculin Interactions},
  author={Philippe R. J. Bois and Robert A. Borgon and Clemens Vonrhein and Tina Izard},
  year={2005}
}
α-Actinin and vinculin orchestrate reorganization of the actin cytoskeleton following the formation of adhesion junctions. α-Actinin interacts with vinculin through the binding of an α-helix (αVBS) present within the R4 spectrin repeat of its central rod domain to vinculin's N-terminal seven-helical bundle domain (Vh1). The Vh1:αVBS structure suggests that αVBS first unravels from its buried location in the triple-helical R4 repeat to allow it to bind to vinculin. αVBS binding then induces… CONTINUE READING

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