Structural Domains in Paramyxovirus Polymerase Independent Structural Domains in the Paramyxovirus Polymerase Protein

@inproceedings{Dochow2011StructuralDI,
  title={Structural Domains in Paramyxovirus Polymerase Independent Structural Domains in the Paramyxovirus Polymerase Protein},
  author={Melanie Dochow and Stefanie A. Krumm and James E. Crowe and Martin L Moore and Richard K Plemper},
  year={2011}
}
Background: RNA-dependent RNA-polymerases of nonsegmented negative-strand RNA viruses (Mononegavirales) harbor multiple catalytic activities. Results: Domain screening and transcomplementation of paramyxovirus polymerase fragments with dimerization tags identifies independent folding-competent domains. Conclusion: Paramyxovirus polymerases harbor at least two independent domains that lack highaffinity interfaces but require molecular compatibility for bioactivity. Significance: First… CONTINUE READING