Structural Determinants of Water Permeability through the Lipid Membrane

  title={Structural Determinants of Water Permeability through the Lipid Membrane},
  author={John C. Mathai and Stephanie Tristram-Nagle and John F. Nagle and Mark Lawrence Zeidel},
  journal={The Journal of General Physiology},
  pages={69 - 76}
Despite intense study over many years, the mechanisms by which water and small nonelectrolytes cross lipid bilayers remain unclear. While prior studies of permeability through membranes have focused on solute characteristics, such as size, polarity, and partition coefficient in hydrophobic solvent, we focus here on water permeability in seven single component bilayers composed of different lipids, five with phosphatidylcholine headgroups and different chain lengths and unsaturation, one with a… CONTINUE READING
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Structure and fl uctuations of charged phosphatidylserine bilayers in the absence of salt

  • K. C. Olbrich, T. McIntosh, D. Needham, E. Evans
  • Biophys . J .
  • 2004