Structural Determinants of Phenotypic Diversity and Replication Rate of Human Prions

Abstract

The infectious pathogen responsible for prion diseases is the misfolded, aggregated form of the prion protein, PrPSc. In contrast to recent progress in studies of laboratory rodent-adapted prions, current understanding of the molecular basis of human prion diseases and, especially, their vast phenotypic diversity is very limited. Here, we have purified… (More)
DOI: 10.1371/journal.ppat.1004832
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