Structural Descriptors of gp120 V3 Loop for the Prediction of HIV-1 Coreceptor Usage

@article{Sander2007StructuralDO,
  title={Structural Descriptors of gp120 V3 Loop for the Prediction of HIV-1 Coreceptor Usage},
  author={Oliver Sander and Tobias Sing and Ingolf Sommer and Andrew J. Low and Peter K. Cheung and P. Richard Harrigan and Thomas Lengauer and Francisco S. Domingues},
  journal={PLoS Computational Biology},
  year={2007},
  volume={3},
  pages={104 - 112}
}
HIV-1 cell entry commonly uses, in addition to CD4, one of the chemokine receptors CCR5 or CXCR4 as coreceptor. Knowledge of coreceptor usage is critical for monitoring disease progression as well as for supporting therapy with the novel drug class of coreceptor antagonists. Predictive methods for inferring coreceptor usage based on the third hypervariable (V3) loop region of the viral gene coding for the envelope protein gp120 can provide us with these monitoring facilities while avoiding… CONTINUE READING

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