Structural Conservation and Functional Diversity of the Poxvirus Immune Evasion (PIE) Domain Superfamily

@inproceedings{Nelson2015StructuralCA,
  title={Structural Conservation and Functional Diversity of the Poxvirus Immune Evasion (PIE) Domain Superfamily},
  author={Christopher A. Nelson and Megan L. Epperson and Sukrit Singh and Jabari I. Elliott and Daved H. Fremont and Elliot J. Lefkowitz and Chris Upton},
  booktitle={Viruses},
  year={2015}
}
Poxviruses encode a broad array of proteins that serve to undermine host immune defenses. Structural analysis of four of these seemingly unrelated proteins revealed the recurrent use of a conserved beta-sandwich fold that has not been observed in any eukaryotic or prokaryotic protein. Herein we propose to call this unique structural scaffolding the PIE (Poxvirus Immune Evasion) domain. PIE domain containing proteins are abundant in chordopoxvirinae, with our analysis identifying 20 likely PIE… CONTINUE READING
Recent Discussions
This paper has been referenced on Twitter 4 times over the past 90 days. VIEW TWEETS
7 Citations
83 References
Similar Papers

References

Publications referenced by this paper.
Showing 1-10 of 83 references

Similar Papers

Loading similar papers…