Structural Consequences of Nucleophosmin Mutations in Acute Myeloid Leukemia*

  title={Structural Consequences of Nucleophosmin Mutations in Acute Myeloid Leukemia*},
  author={Charles G. Grummitt and Fiona M. Townsley and Christopher Mark Johnson and Alan J Warren and Mark Bycroft},
  journal={The Journal of Biological Chemistry},
  pages={23326 - 23332}
Mutations affecting NPM1 (nucleophosmin) are the most common genetic lesions found in acute myeloid leukemia (AML). NPM1 is one of the most abundant proteins found in the nucleolus and has links to the MDM2/p53 tumor suppressor pathway. A distinctive feature of NPM1 mutants in AML is their aberrant localization to the cytoplasm of leukemic cells. This mutant phenotype is the result of the substitution of several C-terminal residues, including one or two conserved tryptophan residues, with a… CONTINUE READING


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