Structural Comparison of Allogeneic and Syngeneic T Cell Receptor–Peptide-Major Histocompatibility Complex Complexes

@article{Luz2002StructuralCO,
  title={Structural Comparison of Allogeneic and Syngeneic T Cell Receptor–Peptide-Major Histocompatibility Complex Complexes},
  author={John Gately Luz and Mingdong Huang and K Christopher Garcia and Markus G. Rudolph and Vasso Apostolopoulos and Luc Teyton and Ian A. Wilson},
  journal={The Journal of Experimental Medicine},
  year={2002},
  volume={195},
  pages={1175 - 1186}
}
The crystal structures of the 2C/H-2K(bm3)-dEV8 allogeneic complex at 2.4 A and H-2K(bm3)-dEV8 at 2.15 A, when compared with their syngeneic counterparts, elucidate structural changes that induce an alloresponse. The Asp77Ser mutation that imbues H-2K(bm3)-dEV8 with its alloreactive properties is located beneath the peptide and does not directly contact the T cell receptor (TCR). However, the buried mutation induces local rearrangement of the peptide itself to preserve hydrogen bonding… CONTINUE READING

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