Structural Characterization of the Extracellular Domain of CASPR2 and Insights into Its Association with the Novel Ligand Contactin1.

@article{RubioMarrero2016StructuralCO,
  title={Structural Characterization of the Extracellular Domain of CASPR2 and Insights into Its Association with the Novel Ligand Contactin1.},
  author={Eva N. Rubio-Marrero and Gabriele Vincelli and Cy M. Jeffries and Tanvir R. Shaikh and Irene S Pakos and Fanomezana M. Ranaivoson and Sventja von Daake and Borries Demeler and Antonella De Jaco and Guy A Perkins and Mark H. Ellisman and Jill Trewhella and Davide Comoletti},
  journal={The Journal of biological chemistry},
  year={2016},
  volume={291 11},
  pages={5788-802}
}
Contactin-associated protein-like 2 (CNTNAP2) encodes for CASPR2, a multidomain single transmembrane protein belonging to the neurexin superfamily that has been implicated in a broad range of human phenotypes including autism and language impairment. Using a combination of biophysical techniques, including small angle x-ray scattering, single particle electron microscopy, analytical ultracentrifugation, and bio-layer interferometry, we present novel structural and functional data that relate… CONTINUE READING