Structural Characterization of a Heparan Sulfate Pentamer Interacting with LAR-Ig1-2.

@article{Gao2018StructuralCO,
  title={Structural Characterization of a Heparan Sulfate Pentamer Interacting with LAR-Ig1-2.},
  author={Qi Gao and Jeong-Yeh Yang and Kelley W Moremen and John G. Flanagan and James H. Prestegard},
  journal={Biochemistry},
  year={2018},
  volume={57 15},
  pages={
          2189-2199
        }
}
Leukocyte common antigen-related (LAR) protein is one of the type IIa receptor protein tyrosine phosphatases (RPTPs) that are important for signal transduction in biological processes, including axon growth and regeneration. Glycosaminoglycan chains, including heparan sulfate (HS) and chondroitin sulfate (CS), act as ligands that regulate LAR signaling. Here, we report the structural characterization of the first two immunoglobulin domains (Ig1-2) of LAR interacting with an HS pentasaccharide… CONTINUE READING

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