Structural Characterization and Interactions of the CFTR Regulatory Region
@inproceedings{Baker2010StructuralCA,
title={Structural Characterization and Interactions of the CFTR Regulatory Region},
author={Jennifer M Baker},
year={2010}
}The intrinsically disordered nonphosphorylated and phosphorylated R region of CFTR and its interactions with NBD1 and SLC26A3 STAS have been characterized at residuespecific resolution, primarily using NMR. Limited chemical shift dispersion indicates that the R region is intrinsically disordered in solution and that no global folding event occurs upon phosphorylation. Chemical shifts of backbone nuclei and sidechain carbons were assigned. SSP values indicate that phosphorylation acts as a…
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