Structural Characteristic of the Initial Unfolded State on Refolding Determines Catalytic Efficiency of the Folded Protein in Presence of Osmolytes

@inproceedings{Warepam2014StructuralCO,
  title={Structural Characteristic of the Initial Unfolded State on Refolding Determines Catalytic Efficiency of the Folded Protein in Presence of Osmolytes},
  author={Marina Warepam and Gurumayum Suraj Sharma and Tanveer Ali Dar and Md. Khurshid Alam Khan and Laishram Rajendrakumar Singh and Sabato d’Auria},
  booktitle={PloS one},
  year={2014}
}
Osmolytes are low molecular weight organic molecules accumulated by organisms to assist proper protein folding, and to provide protection to the structural integrity of proteins under denaturing stress conditions. It is known that osmolyte-induced protein folding is brought by unfavorable interaction of osmolytes with the denatured/unfolded states. The interaction of osmolyte with the native state does not significantly contribute to the osmolyte-induced protein folding. We have therefore… CONTINUE READING

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