Structural Basis of Transcription Activation: The CAP-αCTD-DNA Complex

@article{Benoff2002StructuralBO,
  title={Structural Basis of Transcription Activation: The CAP-αCTD-DNA Complex},
  author={B. Benoff and Huanwang Yang and C. Lawson and G. Parkinson and Jinsong Liu and E. Blatter and Y. Ebright and H. Berman and R. Ebright},
  journal={Science},
  year={2002},
  volume={297},
  pages={1562 - 1566}
}
The Escherichia coli catabolite activator protein (CAP) activates transcription at Plac, Pgal, and other promoters through interactions with the RNA polymerase α subunit carboxyl-terminal domain (αCTD). We determined the crystal structure of the CAP-αCTD-DNA complex at a resolution of 3.1 angstroms. CAP makes direct protein-protein interactions with αCTD, and αCTD makes direct protein-DNA interactions with the DNA segment adjacent to the DNA site for CAP. There are no large-scale conformational… Expand
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