Structural Basis of Transcription: RNA Polymerase II at 2.8 Ångstrom Resolution

@article{Cramer2001StructuralBO,
  title={Structural Basis of Transcription: RNA Polymerase II at 2.8 {\AA}ngstrom Resolution},
  author={Patrick Cramer and David A. Bushnell and Roger D. Kornberg},
  journal={Science},
  year={2001},
  volume={292},
  pages={1863 - 1876}
}
Structures of a 10-subunit yeast RNA polymerase II have been derived from two crystal forms at 2.8 and 3.1 angstrom resolution. Comparison of the structures reveals a division of the polymerase into four mobile modules, including a clamp, shown previously to swing over the active center. In the 2.8 angstrom structure, the clamp is in an open state, allowing entry of straight promoter DNA for the initiation of transcription. Three loops extending from the clamp may play roles in RNA unwinding… 
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  • P. Cramer
  • Biology
    Advances in protein chemistry
  • 2004
...

63 References

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Structure of T7 RNA polymerase complexed to the transcriptional inhibitor T7 lysozyme

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