Structural Basis of Response Regulator Inhibition by a Bacterial Anti-Activator Protein

  title={Structural Basis of Response Regulator Inhibition by a Bacterial Anti-Activator Protein},
  author={Melinda D. Baker and Matthew B. Neiditch},
  booktitle={PLoS biology},
The complex interplay between the response regulator ComA, the anti-activator RapF, and the signaling peptide PhrF controls competence development in Bacillus subtilis. More specifically, ComA drives the expression of genetic competence genes, while RapF inhibits the interaction of ComA with its target promoters. The signaling peptide PhrF accumulates at high cell density and upregulates genetic competence by antagonizing the interaction of RapF and ComA. How RapF functions mechanistically to… CONTINUE READING
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