Structural Basis of Ligand Activation in a Cyclic Nucleotide Regulated Potassium Channel

  title={Structural Basis of Ligand Activation in a Cyclic Nucleotide Regulated Potassium Channel},
  author={G. Clayton and William R. Silverman and L. Heginbotham and J. H. Morais-Cabral},
  • G. Clayton, William R. Silverman, +1 author J. H. Morais-Cabral
  • Published 2004
  • Biology, Medicine
  • Cell
  • Here we describe the initial functional characterization of a cyclic nucleotide regulated ion channel from the bacterium Mesorhizobium loti and present two structures of its cyclic nucleotide binding domain, with and without cAMP. The domains are organized as dimers with the interface formed by the linker regions that connect the nucleotide binding pocket to the pore domain. Together, structural and functional data suggest the domains form two dimers on the cytoplasmic face of the channel. We… CONTINUE READING
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