Structural Basis of Intracellular TGF-β Signaling: Receptors and Smads.

Abstract

Stimulation of the transforming growth factor β (TGF-β) family receptors activates an intracellular phosphorylation-dependent signaling cascade that culminates in Smad transcriptional activation and turnover. Structural studies have identified a number of allosteric mechanisms that control the localization, conformation, and oligomeric state of the… (More)
DOI: 10.1101/cshperspect.a022111

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