Structural Basis for the Inhibition of Histone Deacetylase 8 (HDAC8), a Key Epigenetic Player in the Blood Fluke Schistosoma mansoni

@inproceedings{Marek2013StructuralBF,
  title={Structural Basis for the Inhibition of Histone Deacetylase 8 (HDAC8), a Key Epigenetic Player in the Blood Fluke Schistosoma mansoni},
  author={Martin Marek and Srinivasaraghavan Kannan and Alexander-Thomas Hauser and Marina Moraes Mour{\~a}o and St{\'e}phanie Caby and Vincent Cura and Diana Antonella Stolfa and Karin Schmidtkunz and Julien Lancelot and Luiza L Andrade and Jean-Paul Renaud and Guilherme Oliveira and Wolfgang Sippl and Manfred Jung and Jean Cavarelli and Raymond J. Pierce and Christophe Romier},
  booktitle={PLoS pathogens},
  year={2013}
}
The treatment of schistosomiasis, a disease caused by blood flukes parasites of the Schistosoma genus, depends on the intensive use of a single drug, praziquantel, which increases the likelihood of the development of drug-resistant parasite strains and renders the search for new drugs a strategic priority. Currently, inhibitors of human epigenetic enzymes are actively investigated as novel anti-cancer drugs and have the potential to be used as new anti-parasitic agents. Here, we report that… CONTINUE READING
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