Structural Basis for the Counter-Transport Mechanism of a H+/Ca2+ Exchanger

@article{Nishizawa2013StructuralBF,
  title={Structural Basis for the Counter-Transport Mechanism of a H+/Ca2+ Exchanger},
  author={T. Nishizawa and S. Kita and A. Maturana and Noritaka Furuya and K. Hirata and G. Kasuya and S. Ogasawara and N. Dohmae and T. Iwamoto and R. Ishitani and O. Nureki},
  journal={Science},
  year={2013},
  volume={341},
  pages={168 - 172}
}
Inward-Facing Antiporter Calcium/cation antiporters play a role in regulating the cytosolic calcium concentration by using the electrochemical gradient of other cations to catalyze Ca2+ transport across cell membranes. The structure of a Na+/Ca2+ exchanger in an outward-facing conformation was recently determined. Nishizawa et al. (p. 168, published online 23 May) now report the crystal structure of a H+/Ca2+ exchanger in an inward-facing conformation. Comparison of the structures shows how… Expand
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Dynamic distinctions in the Na+/Ca2+ exchanger adopting the inward- and outward-facing conformational states
Structure-Functional Basis of Ion Transport in Sodium–Calcium Exchanger (NCX) Proteins
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