Structural Basis for the Activation of Cholera Toxin by Human ARF6-GTP

@article{ONeal2005StructuralBF,
  title={Structural Basis for the Activation of Cholera Toxin by Human ARF6-GTP},
  author={Claire J O'Neal and Michael G Jobling and Randall K. Holmes and Wim G. J. Hol},
  journal={Science},
  year={2005},
  volume={309},
  pages={1093 - 1096}
}
The Vibrio cholerae bacterium causes devastating diarrhea when it infects the human intestine. The key event is adenosine diphosphate (ADP)–ribosylation of the human signaling protein GSα, catalyzed by the cholera toxin A1 subunit (CTA1). This reaction is allosterically activated by human ADP-ribosylation factors (ARFs), a family of essential and ubiquitous G proteins. Crystal structures of a CTA1:ARF6-GTP (guanosine triphosphate) complex reveal that binding of the human activator elicits… 
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