Structural Basis for dsRNA Recognition, Filament Formation, and Antiviral Signal Activation by MDA5

@article{Wu2013StructuralBF,
  title={Structural Basis for dsRNA Recognition, Filament Formation, and Antiviral Signal Activation by MDA5},
  author={Bin Wu and Alys Peisley and Claire Richards and Hui Yao and Xiaohui Zeng and Cecilie Lin and Feixia Chu and Thomas Walz and Sun Kyung Hur},
  journal={Cell},
  year={2013},
  volume={152},
  pages={276-289}
}
MDA5, a viral double-stranded RNA (dsRNA) receptor, shares sequence similarity and signaling pathways with RIG-I yet plays essential functions in antiviral immunity through distinct specificity for viral RNA. Revealing the molecular basis for the functional divergence, we report here the crystal structure of MDA5 bound to dsRNA, which shows how, using the same domain architecture, MDA5 recognizes the internal duplex structure, whereas RIG-I recognizes the terminus of dsRNA. We further show that… CONTINUE READING
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