Structural Basis for Selective Recognition of Oligosaccharides by DC-SIGN and DC-SIGNR

@article{Feinberg2001StructuralBF,
  title={Structural Basis for Selective Recognition of Oligosaccharides by DC-SIGN and DC-SIGNR},
  author={Hadar Feinberg and Daniel Mitchell and Kurt Drickamer and William I. Weis},
  journal={Science},
  year={2001},
  volume={294},
  pages={2163 - 2166}
}
Dendritic cell specific intracellular adhesion molecule–3 (ICAM-3) grabbing nonintegrin (DC-SIGN), a C-type lectin present on the surface of dendritic cells, mediates the initial interaction of dendritic cells with T cells by binding to ICAM-3. DC-SIGN and DC-SIGNR, a related receptor found on the endothelium of liver sinusoids, placental capillaries, and lymph nodes, bind to oligosaccharides that are present on the envelope of human immunodeficiency virus (HIV), an interaction that strongly… 
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TLDR
Binding to clustered oligosaccharides may also explain the interaction of these receptors with the gp120 envelope protein of human immunodeficiency virus-1, which contributes to virus infection.
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TLDR
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TLDR
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