Structural Basis for Selective Recognition of Oligosaccharides by DC-SIGN and DC-SIGNR

  title={Structural Basis for Selective Recognition of Oligosaccharides by DC-SIGN and DC-SIGNR},
  author={H. Feinberg and D. Mitchell and K. Drickamer and W. Weis},
  pages={2163 - 2166}
  • H. Feinberg, D. Mitchell, +1 author W. Weis
  • Published 2001
  • Biology, Medicine
  • Science
  • Dendritic cell specific intracellular adhesion molecule–3 (ICAM-3) grabbing nonintegrin (DC-SIGN), a C-type lectin present on the surface of dendritic cells, mediates the initial interaction of dendritic cells with T cells by binding to ICAM-3. DC-SIGN and DC-SIGNR, a related receptor found on the endothelium of liver sinusoids, placental capillaries, and lymph nodes, bind to oligosaccharides that are present on the envelope of human immunodeficiency virus (HIV), an interaction that strongly… CONTINUE READING
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