Structural Basis for Selective Recognition of Oligosaccharides by DC-SIGN and DC-SIGNR
@article{Feinberg2001StructuralBF, title={Structural Basis for Selective Recognition of Oligosaccharides by DC-SIGN and DC-SIGNR}, author={H. Feinberg and D. Mitchell and K. Drickamer and W. Weis}, journal={Science}, year={2001}, volume={294}, pages={2163 - 2166} }
Dendritic cell specific intracellular adhesion molecule–3 (ICAM-3) grabbing nonintegrin (DC-SIGN), a C-type lectin present on the surface of dendritic cells, mediates the initial interaction of dendritic cells with T cells by binding to ICAM-3. DC-SIGN and DC-SIGNR, a related receptor found on the endothelium of liver sinusoids, placental capillaries, and lymph nodes, bind to oligosaccharides that are present on the envelope of human immunodeficiency virus (HIV), an interaction that strongly… CONTINUE READING
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References
SHOWING 1-10 OF 18 REFERENCES
A Novel Mechanism of Carbohydrate Recognition by the C-type Lectins DC-SIGN and DC-SIGNR
- Biology, Medicine
- The Journal of Biological Chemistry
- 2001
- 463
- PDF
Identification of DC-SIGN, a Novel Dendritic Cell–Specific ICAM-3 Receptor that Supports Primary Immune Responses
- Biology, Medicine
- Cell
- 2000
- 1,675
- PDF
DC-SIGN, a Dendritic Cell–Specific HIV-1-Binding Protein that Enhances trans-Infection of T Cells
- Biology, Medicine
- Cell
- 2000
- 2,376
- PDF
DC-SIGN–ICAM-2 interaction mediates dendritic cell trafficking
- Biology, Medicine
- Nature Immunology
- 2000
- 515
A Dendritic Cell–Specific Intercellular Adhesion Molecule 3–Grabbing Nonintegrin (Dc-Sign)–Related Protein Is Highly Expressed on Human Liver Sinusoidal Endothelial Cells and Promotes HIV-1 Infection
- Biology, Medicine
- The Journal of experimental medicine
- 2001
- 341
- PDF
DC-SIGNR, a DC-SIGN homologue expressed in endothelial cells, binds to human and simian immunodeficiency viruses and activates infection in trans
- Biology, Medicine
- Proceedings of the National Academy of Sciences of the United States of America
- 2001
- 293
- PDF
Cutting Edge: DC-SIGN; a Related Gene, DC-SIGNR; and CD23 Form a Cluster on 19p131 2
- Biology, Medicine
- The Journal of Immunology
- 2000
- 255
- PDF
DC-SIGN Interactions with Human Immunodeficiency Virus Type 1 and 2 and Simian Immunodeficiency Virus
- Biology, Medicine
- Journal of Virology
- 2001
- 221
- PDF
Structure of a C-type mannose-binding protein complexed with an oligosaccharide
- Chemistry, Medicine
- Nature
- 1992
- 804