Structural Basis for Recognition of the Pore-Forming Toxin Intermedilysin by Human Complement Receptor CD59

Abstract

Pore-forming proteins containing the structurally conserved membrane attack complex/perforin fold play an important role in immunity and host-pathogen interactions. Intermedilysin (ILY) is an archetypal member of a cholesterol-dependent cytolysin subclass that hijacks the complement receptor CD59 to make cytotoxic pores in human cells. ILY directly competes… (More)
DOI: 10.1016/j.celrep.2013.04.029

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@inproceedings{Johnson2013StructuralBF, title={Structural Basis for Recognition of the Pore-Forming Toxin Intermedilysin by Human Complement Receptor CD59}, author={Steven Johnson and Nicholas J. Brooks and Richard A.G. Smith and Susan M Lea and Doryen Bubeck}, booktitle={Cell reports}, year={2013} }