Structural Basis for Linezolid Binding Site Rearrangement in the Staphylococcus aureus Ribosome

Abstract

An unorthodox, surprising mechanism of resistance to the antibiotic linezolid was revealed by cryo-electron microscopy (cryo-EM) in the 70S ribosomes from a clinical isolate of Staphylococcus aureus This high-resolution structural information demonstrated that a single amino acid deletion in ribosomal protein uL3 confers linezolid resistance despite being… (More)
DOI: 10.1128/mBio.00395-17

Topics

2 Figures and Tables

Blog articles referencing this paper

Slides referencing similar topics