Structural Basis for Kinase-Mediated Macrolide Antibiotic Resistance.

Abstract

The macrolides are a class of antibiotic, characterized by a large macrocyclic lactone ring that can be inactivated by macrolide phosphotransferase enzymes. We present structures for MPH(2')-I and MPH(2')-II in the apo state, and in complex with GTP analogs and six different macrolides. These represent the first structures from the two main classes of… (More)
DOI: 10.1016/j.str.2017.03.007

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