Structural Basis for DNA Binding Specificity by the Auxin-Dependent ARF Transcription Factors

@article{Boer2014StructuralBF,
  title={Structural Basis for DNA Binding Specificity by the Auxin-Dependent ARF Transcription Factors},
  author={D. Roeland Boer and Alejandra Freire-Rios and Willy A.M. van den Berg and Terrens N V Saaki and Iain W. Manfield and Stefan Kepinski and Irene L{\'o}pez-Vidrieo and Jos{\'e} Manuel Franco-Zorrilla and Sacco C. de Vries and Roberto Solano and Dolf Weijers and M. Dolores Coll},
  journal={Cell},
  year={2014},
  volume={156},
  pages={577-589}
}
Auxin regulates numerous plant developmental processes by controlling gene expression via a family of functionally distinct DNA-binding auxin response factors (ARFs), yet the mechanistic basis for generating specificity in auxin response is unknown. Here, we address this question by solving high-resolution crystal structures of the pivotal Arabidopsis developmental regulator ARF5/MONOPTEROS (MP), its divergent paralog ARF1, and a complex of ARF1 and a generic auxin response DNA element (AuxRE… CONTINUE READING
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