Structural Basis for Conserved Regulation and Adaptation of the Signal Recognition Particle Targeting Complex.

@article{Wild2016StructuralBF,
  title={Structural Basis for Conserved Regulation and Adaptation of the Signal Recognition Particle Targeting Complex.},
  author={Klemens Wild and Gert Bange and Domantas Motiejūnas and Judith Kribelbauer and Astrid Hendricks and Bernd Segnitz and Rebecca C. Wade and Irmgard Sinning},
  journal={Journal of molecular biology},
  year={2016},
  volume={428 14},
  pages={2880-97}
}
The signal recognition particle (SRP) is a ribonucleoprotein complex with a key role in targeting and insertion of membrane proteins. The two SRP GTPases, SRP54 (Ffh in bacteria) and FtsY (SRα in eukaryotes), form the core of the targeting complex (TC) regulating the SRP cycle. The architecture of the TC and its stimulation by RNA has been described for the bacterial SRP system while this information is lacking for other domains of life. Here, we present the crystal structures of the GTPase… CONTINUE READING
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