Structural Basis for Antibody Recognition of Lipid A: INSIGHTS TO POLYSPECIFICITY TOWARD SINGLE-STRANDED DNA.

@article{HajiGhassemi2015StructuralBF,
  title={Structural Basis for Antibody Recognition of Lipid A: INSIGHTS TO POLYSPECIFICITY TOWARD SINGLE-STRANDED DNA.},
  author={Omid Haji-Ghassemi and Sven M{\"u}ller-Loennies and Teresa Rodriguez and Lore Brade and Paul Kosma and Helmut Brade and Stephen Vincent Ashley Evans},
  journal={The Journal of biological chemistry},
  year={2015},
  volume={290 32},
  pages={
          19629-40
        }
}
Septic shock is a leading cause of death, and it results from an inflammatory cascade triggered by the presence of microbial products in the blood. Certain LPS from Gram-negative bacteria are very potent inducers and are responsible for a high percentage of septic shock cases. Despite decades of research, mAbs specific for lipid A (the endotoxic principle of LPS) have not been successfully developed into a clinical treatment for sepsis. To understand the molecular basis for the observed… CONTINUE READING
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