Structural Basis for Acyl Acceptor Specificity in the Achromobactin Biosynthetic Enzyme AcsD

@inproceedings{Schmelz2011StructuralBF,
  title={Structural Basis for Acyl Acceptor Specificity in the Achromobactin Biosynthetic Enzyme AcsD},
  author={Stefan Schmelz and Catherine H. Botting and Lijiang Song and Nadia F. Kadi and Gregory L Challis and James H. Naismith},
  booktitle={Journal of molecular biology},
  year={2011}
}
Siderophores are known virulence factors, and their biosynthesis is a target for new antibacterial agents. A non-ribosomal peptide synthetase-independent siderophore biosynthetic pathway in Dickeya dadantii is responsible for production of the siderophore achromobactin. The D. dadantii achromobactin biosynthesis protein D (AcsD) enzyme has been shown to enantioselectively esterify citric acid with l-serine in the first committed step of achromobactin biosynthesis. The reaction occurs in two… CONTINUE READING