Structural Analysis of the Mechanism of Inhibition and Allosteric Activation of the Kinase Domain of Her 2

@inproceedings{Aertgeerts2011StructuralAO,
  title={Structural Analysis of the Mechanism of Inhibition and Allosteric Activation of the Kinase Domain of Her 2},
  author={Kathleen Aertgeerts and Robert J. Skene and Jason Yano and Bi-Ching Sang and Hua Song Zou and Gyorgy Snell and Andy Jennings and Keiji Iwamoto and Noriyuki Habuka and Aki Hirokawa and Tomoyasu Ishikawa and Toshimasa Tanaka and Hiroshi Miki and Yoshikazu Ohta and Satoshi Sogabe},
  year={2011}
}
Aberrant signaling of ErbB family members, HER2 and EGFR, is implicated in many human cancers and HER2 expression is predictive of human disease recurrence and prognosis. Small molecule kinase inhibitors of EGFR and of both HER2 and EGFR have received approval for the treatment of cancer. We present the first high resolution crystal structure of the kinase… CONTINUE READING