Structural Analysis of Staphylococcus aureus Serine/Threonine Kinase PknB

@inproceedings{Rakette2012StructuralAO,
  title={Structural Analysis of Staphylococcus aureus Serine/Threonine Kinase PknB},
  author={Sonja Rakette and Stefanie Donat and Knut Ohlsen and Thilo Stehle},
  booktitle={PloS one},
  year={2012}
}
Effective treatment of infections caused by the bacterium Staphylococcus aureus remains a worldwide challenge, in part due to the constant emergence of new strains that are resistant to antibiotics. The serine/threonine kinase PknB is of particular relevance to the life cycle of S. aureus as it is involved in the regulation of purine biosynthesis, autolysis, and other central metabolic processes of the bacterium. We have determined the crystal structure of the kinase domain of PknB in complex… CONTINUE READING
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References

Publications referenced by this paper.
SHOWING 1-10 OF 51 REFERENCES

Protein kinases: evolution of dynamic regulatory proteins.

  • Trends in biochemical sciences
  • 2011
VIEW 10 EXCERPTS
HIGHLY INFLUENTIAL

Xds. Acta crystallographica Section D, Biological crystallography

W Kabsch
  • 2010
VIEW 2 EXCERPTS
HIGHLY INFLUENTIAL