Structural Analysis of Staphylococcus aureus Serine/Threonine Kinase PknB

@article{Rakette2012StructuralAO,
  title={Structural Analysis of Staphylococcus aureus Serine/Threonine Kinase PknB},
  author={Sonja Rakette and S. Donat and K. Ohlsen and T. Stehle},
  journal={PLoS ONE},
  year={2012},
  volume={7}
}
Effective treatment of infections caused by the bacterium Staphylococcus aureus remains a worldwide challenge, in part due to the constant emergence of new strains that are resistant to antibiotics. The serine/threonine kinase PknB is of particular relevance to the life cycle of S. aureus as it is involved in the regulation of purine biosynthesis, autolysis, and other central metabolic processes of the bacterium. We have determined the crystal structure of the kinase domain of PknB in complex… Expand
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