Structural Analysis and Identification of Novel Isoforms of the Circadian Clock Gene period in the Silk Moth Bombyx mori

@inproceedings{Takeda2004StructuralAA,
  title={Structural Analysis and Identification of Novel Isoforms of the Circadian Clock Gene period in the Silk Moth Bombyx mori},
  author={Yukimasa Takeda and Yoshiro Chuman and Naoto Shirasu and Seiji Sato and Ayami Matsushima and Atsushi Kaneki and Yoshiya Tominaga and Yasuyuki Shimohigashi and Miki Shimohigashi},
  booktitle={Zoological science},
  year={2004}
}
Abstract The molecular basis of the circadian clock is an autoregulatory feedback loop in which the PAS domain-containing protein PERIOD periodically inhibits its own transcription. In the present study on PERIOD of the silk moth Bombyx mori, we have cloned two distinct period mRNA homologues with different PAS domain sequences either with or without the pentapeptide GTQEK. A period cDNA fragment first amplified by PCR exhibited a 15 bp-deleted nucleotide sequence in the PAS domain, compared… CONTINUE READING

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