Structural Adaptations in a Membrane Enzyme That Terminates Endocannabinoid Signaling

@article{Bracey2002StructuralAI,
  title={Structural Adaptations in a Membrane Enzyme That Terminates Endocannabinoid Signaling},
  author={M. Bracey and M. Hanson and Kim R Masuda and R. Stevens and B. Cravatt},
  journal={Science},
  year={2002},
  volume={298},
  pages={1793 - 1796}
}
  • M. Bracey, M. Hanson, +2 authors B. Cravatt
  • Published 2002
  • Biology, Medicine
  • Science
  • Cellular communication in the nervous system is mediated by chemical messengers that include amino acids, monoamines, peptide hormones, and lipids. An interesting question is how neurons regulate signals that are transmitted by membrane-embedded lipids. Here, we report the 2.8 angstrom crystal structure of the integral membrane protein fatty acid amide hydrolase (FAAH), an enzyme that degrades members of the endocannabinoid class of signaling lipids and terminates their activity. The structure… CONTINUE READING
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