Structural Adaptations in a Membrane Enzyme That Terminates Endocannabinoid Signaling

  title={Structural Adaptations in a Membrane Enzyme That Terminates Endocannabinoid Signaling},
  author={M. Bracey and M. Hanson and Kim R Masuda and R. Stevens and B. Cravatt},
  pages={1793 - 1796}
  • M. Bracey, M. Hanson, +2 authors B. Cravatt
  • Published 2002
  • Biology, Medicine
  • Science
  • Cellular communication in the nervous system is mediated by chemical messengers that include amino acids, monoamines, peptide hormones, and lipids. An interesting question is how neurons regulate signals that are transmitted by membrane-embedded lipids. Here, we report the 2.8 angstrom crystal structure of the integral membrane protein fatty acid amide hydrolase (FAAH), an enzyme that degrades members of the endocannabinoid class of signaling lipids and terminates their activity. The structure… CONTINUE READING
    440 Citations
    Membrane lipids are key modulators of the endocannabinoid-hydrolase FAAH.
    • 32
    • PDF
    Fatty Acid Amide Hydrolases: An Expanded Capacity for Chemical Communication?
    • 4
    Structure and function of fatty acid amide hydrolase.
    • 545
    • PDF
    Structural analysis of a plant fatty acid amide hydrolase provides insights into the evolutionary diversity of bioactive acylethanolamides
    • 5
    • Highly Influenced
    • PDF
    Fatty Acid Amide Hydrolase: From Characterization to Therapeutics
    • 53
    • PDF
    Endocannabinoid biosynthesis and inactivation, from simple to complex.
    • 138
    • PDF
    Occurrence, metabolism, and prospective functions of N-acylethanolamines in plants.
    • K. Chapman
    • Biology, Medicine
    • Progress in lipid research
    • 2004
    • 98


    Structure and function of a squalene cyclase.
    • 366
    • PDF
    Exceptionally potent inhibitors of fatty acid amide hydrolase: the enzyme responsible for degradation of endogenous oleamide and anandamide.
    • D. Boger, H. Sato, +7 authors B. Cravatt
    • Chemistry, Medicine
    • Proceedings of the National Academy of Sciences of the United States of America
    • 2000
    • 236
    • PDF
    Pharmacological activity of fatty acid amides is regulated, but not mediated, by fatty acid amide hydrolase in vivo.
    • 220
    • PDF
    A new perspective on cannabinoid signalling: complimentary localization of fatty acid amide hydrolase and the CB1 receptor in rat brain.
    • 293
    An anorexic lipid mediator regulated by feeding
    • 617