Structural, kinetic and chemical mechanism of isocitrate dehydrogenase-1 from Mycobacterium tuberculosis.

Abstract

Mycobacterium tuberculosis (Mtb) is the leading cause of death due to a bacterial infection. The success of the Mtb pathogen has largely been attributed to the nonreplicating, persistence phase of the life cycle, for which the glyoxylate shunt is required. In Escherichia coli, flux through the shunt is controlled by regulation of isocitrate dehydrogenase… (More)
DOI: 10.1021/bi400037w

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@article{Quartararo2013StructuralKA, title={Structural, kinetic and chemical mechanism of isocitrate dehydrogenase-1 from Mycobacterium tuberculosis.}, author={Christine E Quartararo and Saugata Hazra and Timin Hadi and John S Blanchard}, journal={Biochemistry}, year={2013}, volume={52 10}, pages={1765-75} }