Structural, biochemical and in vivo characterization of MtrR-mediated resistance to innate antimicrobials by the human pathogen Neisseria gonorrhoeae.

@article{Beggs2019StructuralBA,
  title={Structural, biochemical and in vivo characterization of MtrR-mediated resistance to innate antimicrobials by the human pathogen Neisseria gonorrhoeae.},
  author={Grace A Beggs and Yaramah M. Zalucki and Nicholas Gene Brown and Sheila Rastegari and Robin K. S. Phillips and B. V. Venkataram Prasad and William Maurice Shafer and Muthiah Kumaraswami and Richard G Brennan},
  journal={Journal of bacteriology},
  year={2019}
}
Neisseria gonorrhoeae responds to host-derived antimicrobials by inducing the expression of the mtrCDE-encoded multidrug efflux pump, which expels microbicides such as bile salts, fatty acids, and multiple extrinsically administered drugs from the cell. In the absence of these cytotoxins, the TetR-family member, MtrR, represses the mtrCDE genes. Although antimicrobial-dependent derepression of mtrCDE is clear, the physiological inducers of MtrR are unknown. Here, we report the crystal structure… CONTINUE READING
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