Strongly amphiphilic photosensitizers are not substrates of the cancer stem cell marker ABCG2 and provides specific and efficient light-triggered drug delivery of an EGFR-targeted cytotoxic drug.

@article{Selbo2012StronglyAP,
  title={Strongly amphiphilic photosensitizers are not substrates of the cancer stem cell marker ABCG2 and provides specific and efficient light-triggered drug delivery of an EGFR-targeted cytotoxic drug.},
  author={P K Selbo and Anette Weyergang and M S Eng and Monica Bostad and Gunhild Mari M{\ae}landsmo and Anders H\ogset and Kristian Berg},
  journal={Journal of controlled release : official journal of the Controlled Release Society},
  year={2012},
  volume={159 2},
  pages={197-203}
}
A wide range of anti-cancer drugs are substrates of the ATP-binding cassette transporter ABCG2/CD338/BCRP/MXR, which is thought to play an important role in multi-drug resistance (MDR) and protection of cancer stem cells (CSC) against chemotherapeutics and photodynamic therapy (PDT). Hence, it is of importance to develop drugs that are not substrates of… CONTINUE READING