Stronger antinociceptive efficacy of opioids at the injured nerve trunk than at its peripheral terminals in neuropathic pain.

@article{Labuz2013StrongerAE,
  title={Stronger antinociceptive efficacy of opioids at the injured nerve trunk than at its peripheral terminals in neuropathic pain.},
  author={Dominika Labuz and Halina Machelska},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={2013},
  volume={346 3},
  pages={535-44}
}
Activation of opioid receptors on peripheral sensory neurons has the potential for safe pain control, as it lacks centrally mediated side effects. While this approach often only partially suppressed neuropathic pain in animal models, opioids were mostly applied to animal paws although neuropathy was induced at the nerve trunk. Here we aimed to identify the most relevant peripheral site of opioid action for efficient antinociception in neuropathy. On days 2 and 14 following a chronic… CONTINUE READING
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